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Veeam Backups of Horizon Desktop VMs intermittently failing with "A digest operation has failed."

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Overview The following describes an issue I've been dealing with for some time, which I really only began to encounter after upgrading to Veeam Backup & Replication v12.   My current organization manages thousands of Horizon desktops spread across many different datacenters across the globe.  Each site is managed by at least one VMware vCenter server, which then houses multiple Horizon Desktop pods.  We use Veeam Backup & Replication v12 to perform vm-level backups of critical virtual infrastructure, including desktop image templates and full-clone desktops.  Occasionally, these jobs report a failure, as one or more VMs fails to backup due to the following errors: 4:07:17 AM Failed to create VM snapshot. Error: CreateSnapshot failed, vmRef vm-224105, timeout 1800000, snName VEEAM BACKUP TEMPORARY SNAPSHOT, snDescription Please do not delete this snapshot. It is being used by Veeam Backup., memory False, quiesce False 00:02 4:07:29 AM Error: An erro...